مشاهده ی مقالات علمی ویژه ی متخصصین

Dietary supplementation with Allium hirtifolium and/or Astragalus hamosus improved ‎memory .

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Abstract

Allium hirtifolium Boiss and Astragalus hamosus L. are mentioned in Iranian traditional medicine ‎documentation as therapy for a kind of dementia with the features and symptoms similar to those ‎of Alzheimer's disease (AD). In the present study, the effects of these herbs on neuro-‎inflammation and memory have been evaluated as new therapies in amyloid beta (Aβ) induced ‎memory impairment model. Separate groups of rats were fed with A. hirtifolium or A. hamosus ‎extract (both 100 mg/kg/day) started one week before stereotaxic surgery to 24 hours before ‎behavioral ‎testing (totally, for 16 successive days). The effects of oral administration of ‎mentioned extracts on‎‏ the ‏memory and neuro-inflammation were assessed in the Aβ-injected rats. ‎The results of this study showed that oral administration of both A. hirtifolium and A. hamosus ‎improved the memory, examined by using Y-maze test and shuttle box apparatus. Also, Western ‎blotting analysis of cyclooxygenase-2, interleukin-1β and tumor necrosis factor-α showed that ‎these herbs have ameliorating effects against the neuro-inflammation caused by Aβ. These ‎findings suggest that the use of A. hirtifolium and A. hamosus as herbal therapy may be suitable ‎for decreasing AD-related symptoms and treatment of other neurodegenerative disorders.‎.

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